Preventive mitochondrial replacement

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منابع مشابه

The Challenges of Mitochondrial Replacement

1 Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom, 2 Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, United Kingdom, 3 Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Ore...

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Mitochondrial Replacement: Ethics And Identity

Mitochondrial replacement techniques (MRTs) have the potential to allow prospective parents who are at risk of passing on debilitating or even life-threatening mitochondrial disorders to have healthy children to whom they are genetically related. Ethical concerns have however been raised about these techniques. This article focuses on one aspect of the ethical debate, the question of whether th...

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Risks inherent to mitochondrial replacement.

T he UK Parliament recently debated and then approved legislation to allow mitochondrial replacement (MR) to be used in the clinic. However, we are concerned that some of the science of MR has been misunderstood or otherwise given only fleeting consideration. We set out our arguments below and offer a way forward to ensure that MR can safely deliver the health benefits it promises for those suf...

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Mitochondrial replacement to prevent the transmission of mitochondrial DNA disease

M itochondrial medicine has seen major advances over recent years. The development of new genetic technology has enabled the genetic diagnosis to be established in an increasing number of patients. This has led to a recognition that mitochondrial diseases are not rare, but one of the most common group of genetic diseases. Associated with these advances, there have been undoubted improvements in...

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Preventive maintenance and replacement policies for deteriorating production systems

This paper presents a special case of integration of the preventive maintenance into the repair/replacement policy of a failure-prone system. The machine of the considered system exhibits increasing failure intensity and increasing repair times. To reduce the failure rate and subsequent repair times following a failure, there is an incentive to perform preventive maintenance on the machine befo...

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ژورنال

عنوان ژورنال: Chemistry & Biology

سال: 1997

ISSN: 1074-5521

DOI: 10.1016/s1074-5521(97)90284-2